Our physical environment is a major determinant of human health. Recent environmental changes, such as urbanization, climate change, and air pollution, put significant pressure on human health. These so-called ‘wicked problems’ are complex and are often governed by a range of sectors and agents, often acting in silos. Current regulatory approaches are therefore fragmented, which undermines holistic legal solutions that take account of the interdependent relationship between human health and our physical environment. Key examples are asthma and allergies resulting from air pollution, and antimicrobial resistance driven by agricultural practices (among others).